Izinga eliphakanyisiwe le-Homocysteine nezinkinga zokukhulelwa
Uma ngabe unesisu esiphuthumayo njalo, udokotela wakho kungenzeka ukuthi watusa ukuhlola izinga le-homocysteine egazini lakho. Yini ngempela i-homocysteine? I-homocysteine ixhunyaniswa kanjani nokukhulelwa kwesisu nezinye izinkinga zokukhulelwa?
Kuyini i-Homocysteine?
I-homocysteine uhlobo lwama-amino acid olutholakala ngokwemvelo emzimbeni. Emazingeni avamile, akuyona eyingozi, kodwa amazinga aphakanyisiwe atholakala ukuthi ahlotshaniswa nokukhulelwa kwesisu kanye nesifo senhliziyo.
Izinga eliphezulu le-Homocysteine
Izinga eliphakeme le-homocysteine egazini liphumela esimweni esibizwa ngokuthi i-hypercoagulability. Izwi elithi coagulation libhekisela ekugqatsheni kwegazi, futhi i-hypercoagulability kusho ukuthi i-blood clots kalula kunalokho okufanele.
Uma kwenzeka lokhu emithanjeni yegazi, njengemithambo ye-coronary, ingase ibe negalelo emavinini avimbela imithwalo yegazi eyenza isifo se-coronary isifo.
Ngokukhulelwa, kucatshangwa ukuthi lawa maqabunga amancane egazi angase avimbele imithwalo yegazi emaplascenta, okuholela ekutheni isisu siphume.
I-Homocysteine ephakeme neHlangano lokuHlala kwabantu
I-homocysteine ephakanyisiwe engakaze ibonakale ibangele ukukhulelwa kwesisu, kodwa kunezinye izinto ezijwayelekile ezihambisana neminye imibandela eyaziwa ukuthi iholele ekutheni i-miscarriages. Isimo esisodwa, okuthiwa i- antiphospholipid syndrome , singabangela kokubili ukukhulelwa kwesisu kanye nesifo senhliziyo ngendlela efanako.
Okunye Ukukhulelwa Ukukhulelwa
I-homocysteine ephakanyisiwe yinkinga eqinisekisiwe yezinye izinkinga ekukhutheni kubandakanya:
- Ukuzala okuncishisiwe
- Amaphutha okuthuthukiswa kokuzalwa, njengeziphambeko ze-neural tube ezifana ne- anencephaly
- Preeclampsia
- Ukunciphisa ukukhula kwe-intrauterine
Njengokukhulelwa kwesisu, ubufakazi buphikisana ngokuthi amazinga aphezulu okuthiwa yi-homocysteine abangela ezinye izinkinga zokukhulelwa njenge:
- Ukuphazamiseka kwamapulazi
- I-Down syndrome
Ukuphikisana Ngokuhlola Ukugaya I-Plasma Homocysteine (tHcy) ekukhulelweni
Uma udokotela wakho ehlola izinga lakho le-homocysteine, kubalulekile ukwazi ukuthi amazinga ajwayelekile e-homocysteine ahamba kahle ngesikhathi sokukhulelwa. Ngamanye amazwi, izinga elibanjwe ngesikhathi esisodwa ngesikhathi, kungenzeka ukuthi, limelela ukuthi amazinga akho angakanani isikhathi. Kunezici eziningana zokudla okunomsoco nokuphila okuholela ekushintsheni kwamalanga nosuku ezingeni. Ngaphezu kwalokho, izinguquko ezithinta ivolumu yegazi ezihlobene nokukhulelwa kuhlangene nezinguquko eziningi ze-hormone zingabangela amazinga ngesikhathi sokukhulelwa okungasho ukuthi amazinga akho ayenjani uma ungakhulelwe.
I-Metabolism ne-Genetics yamazinga akwa-Homocysteine
Uma unezinga eliphezulu le-homocysteine, i-genetics yakho ingaba imbangela.
Abantu abanokushintshashintsha kwegciwane le- MTHFR , ikakhulukazi ukuhlukahluka kwe-C677T, kungenzeka ukuthi banamazinga aphezulu okuthiwa yi-homocysteine. Futhi ezinye izifundo ziye zathola ukuhlanganiswa phakathi kwezinto ze-gene ze-MTHFR kanye nokwanda kwengozi yokukhulelwa komzimba. Imfundiso ehamba phambili ngemuva kwenhlangano yukuthi amazinga aphezulu okuthiwa yi-homocysteine kubantu abanezifo zegciwane le-MTHFR bafaka ingozi yokukhulelwa komzimba.
Abanye odokotela bahlola ukuhlukahluka kwegciwane le-MTHFR njengengxenye yokuphindaphinda kokuhlolwa kokukhipha isisu .
Abanye banomuzwa wokuthi kuyigugu kakhulu ukuhlola homocysteine ngoba akuwona wonke umuntu onama-gene e-MTHFR azoba namazinga aphezulu e-amino acid.
Izimbangela
I-MTHFR i-variants gene is hhayi kuphela imbangela ye-homocysteine ephezulu.
I-MTHFR i-variants gene is hhayi kuphela imbangela ye-homocysteine ephezulu. Umzimba wakho usebenzisa izakhi zomzimba we- folic acid , i-vitamin B6 ne-vitamin B12 ukuze ihlanganise umzimba, noma isebenzise phezulu, i-homocysteine. Abantu abangenayo kulawo mavithamini bangaba namazinga aphezulu e-homocysteine.
Izimo ezihlukahlukene zempilo ezitholakalayo kanye nemithi zingase zihlotshaniswe namazinga aphezulu okuthiwa yi-homocysteine.
Ezinye izingozi zempilo
Nakuba indima eqondile engaziwa, amazinga e-homocysteine aphakanyisiwe avele ekuphefumuleni kwegazi, ukuhlaselwa yinhliziyo, ukushaya isifo, ukucindezeleka kwengqondo, isifo sikaPalinson, isifo se-multiple sclerosis, nesifo sokufa.
Kucatshangwa ukuthi amazinga aphakanyisiwe we-homocysteine egazini angase abe nemiphumela emibi eqondile kokubili isistimu ye-vascular and nervous.
Ukwelapha i-Homocysteine ephakanyisiwe Kuzohlukana okungajwayelekile
Azikho izincomo ezisemthethweni zokuhlola amazinga ka-homocysteine kwabesifazane abanesisu sokuphumula, futhi azikho izinqubo zokwelapha eziphakanyiswayo emhlabeni wonke zokuphatha amazinga aphakeme ase-homocysteine kubesifazane abatholakalayo ukuba nabo.
Kodwa abanye odokotela bahlola i-homocysteine (noma i-MTHFR gene variants) kubantu besifazane abanokulahlekelwa okukhulelwa njalo futhi batusa ukwelashwa ngisho nangaphandle kokungeniswa kwezincomo ezisemthethweni.
Incomo evamile kubantu besifazane abanezinga eliphakeme le-homocysteine ukuthatha amanani aphezulu we-folic acid nama-vithamini B ukuze kuthuthukiswe umzimba we-homocysteine. Yenza lokhu kuphela ngezincomo zodokotela wakho, kodwa, njengoba amazinga aphakeme alawa mavithamini angabangeli nje imiphumela emibi kepha angaphazamisa ukungena kwamanye amavithamini. Kulabo abanezimpawu zegciwane le-MTHFR, i-supplemental folic acid ayitholakalanga ukunciphisa ingozi yokukhulelwa kwesisu.
Odokotela abambalwa bangase batuse ukwelapha okuvimbela ama-anti-clotting, njenge- heparin noma i -aspirin ye-dose ephansi , ukuze kuvinjelwe ama-clots egazi ekubuneni ngesikhathi sokukhulelwa, kodwa lo mkhuba awuyena ojwayelekile.
Ngokujabulisayo, kunezifundo eziqhubekayo zibheke izimpendulo zemibuzo emibili ukuthi iyiphi indima ephezulu ye-homocysteine ekukhulelwe kanye nendlela engcono kakhulu yokwelapha lokhu uma ikhona.
Imithombo:
Ansari, R., Mahta, A., Mallack, E., no J. Luo. I-Hyperhomocysteinemia ne-Neurological Disorders: Ukubuyekeza. Journal of Neurology Clinic . 2014. 10 (4): 281-8.
UHekmatdoost, A., Vahid, F., Yari, Z., Sadeghi, M., Eini-Zinab, J., Lakpour, N., noS S. Arefi. I-Methyltetrahydrofolate vs Folic Acid Supplementation nge-Idiopathic Ukuthutha Ngokuphindaphindiwe Ngokuhlonishwa Kwama-Methylenetetrahydrofolate Ukukhishwa Kwe-C677T ne-A1298C I-Polymorphisms: Isivivinyo Esilawulwe Ngokungahleliwe. PLoS One . 2015. 10 (12): e0143569.
ULevin, B., no-E. Varga. I-MTHFR: Ukubhekana nezidakamizwa ze-Genetic Counseling Dilemmas Ngokusebenzisa Izincwadi Ezisekelwe Ebufakazi. I-Journal ye-Genetic Counseling . 2016. 25 (5): 901-11.
Puri, M., Kaur, L., Walia, G., Mukhopadhhyay, R., Sachdeva, M., Triveldi, S., Ghosh, P., noK. Saraswathy. I-MTHFR C677T I-polymorphism, i-Folate, i-Vitamin B12 ne-Homocysteine ekulahlekeni okukhulelwa okujwayelekile: Ukutadisha Kwamacala Ephakathi Kwabesifazane baseNyakatho Indian. I-Journal ye-Medicine ye-Perinatal . 2013. 41 (5): 549-54.
UMurphy, M., noJerandez-Ballart. Homocysteine in Ukukhulelwa. Kuthuthukile emtholampilo yezokwelapha . 2011. 53: 105-37.