Kuyini i-GnRH, indlela esebenza ngayo, kanye nokwelashwa ne-GnRH
I-GnRH isichazamazwi se-gonadotropin-release hormone. Le hormone ikhishwa yi-hypothalamus ebuchosheni.
I-GnRH yenza ama-receptors emgodini we-pituitary wangaphakathi. I-GnRH isho umgogodla we-pituitary ukukhulula amahomoni e- gonadotropin follicone-evuselela i-hormone (FSH) ne-luteinizing hormone ( LH ).
I-FSH ne-LH bese isenza ama-ovarikazi kwabesifazane nakuma-testes emadodeni.
Zenza ama-ovari avuthwe futhi agqugquzele amaqanda, futhi, emadodeni, enza ukuba izivivinyo zivuthiwe futhi zikhiqize isidoda.
I-FSH ne-LH ibuye ivuse ama-ovari nama-testes ukukhulula ama-hormone abo.
- Ama-ovari, i-estrogen, i-progesterone, ne-testosterone zikhiqizwa.
- Kulezi zivivinyo, i-testosterone ne-estrogen ikhishwa.
I-GnRH ikhishwa emipulini hhayi ngokuqhubekayo.
Emadodeni, lezi zindlala zifika ngesilinganiso esihle kakhulu.
Kwabesifazane, imvamisa yezimfutho ziyahlukahluka kuye ngokuthi umzimba usekupheleni komjikelezo. Isibonelo, ngaphambi nje kokuvuthwa kwegazi, i-GnRH impulse ivame kakhulu.
Amanye Amagama we-GnRH
- Ukukhipha i-hormone-release hormone (LHRH)
- I-hormone-ukukhipha i-hormone
- I-Luliberin (imishanguzo emithanjeni eyenzeka njenge-GnRH emzimbeni)
- I-Gonadorelin (imishanguzo enomzimba eyenza njenge-GnRH emzimbeni)
Ukuhlola NgeGonadorelin
I-Gonadorelin imithi eyenza njenge-hormone GnRH emzimbeni.
Kungasetshenziselwa ukuhlolwa kwezokwelapha noma njengokwelashwa kokubambezeleka kokubeletha noma ukungasebenzi.
Ukuhlola ngokuvamile kuhilela ukwamukela ukujova kwaleli hormone ngesikhathi esithile.
Okokuqala, uzoba nokudweba kwegazi, ngaphambi kokujova nge-hormone.
Khona-ke, ngesikhathi esithile, umjovo we-gonadorelin nje ngaphansi kwesikhumba kuya ezicubu ezinamafutha.
Okulandelayo, emva kwesikhathi esithile esethiwe, uzobe uthola igazi lakho futhi.
Le nqubo - injection elandelwa ukudweba kwegazi - izoqhubeka. Imiphumela izobe ihlaziywe ebhodini.
Lokhu kuhlolwa kungenziwa ezinganeni ezinenkinga yokukhulelwa noma abantu abadala abanokungalingani kwe-hormonal okusobala.
Ukwelapha neGonadorelin ngePut pump
Abesifazane abangenayo i-ovulating bangaphathwa nge-gonadorelin nge-Putrepulse pump. Lokhu kwenziwa uma ukungabikho kwe-GnRH kuyimbangela yokugcoba.
Amadoda angakhiqizi isisu angabuye aphathwe ngamapompo aseLutrepulse.
Ipompi inikeza umthamo olinganiselwe njalo emaminithini angu-90 ngaphezu kwamasonto.
Ngemva kokuqala ukwelashwa, kwabesifazane, ngokuvamile kuthatha amasonto amabili kuya kwamathathu ukuze ukuvuthwa kwenzeke. Ngemuva kwe-ovulation, ukwelashwa kuvame ukuqhubeka namanye amasonto amabili ngokusebenzisa isigaba se-luteal.
GnRH-a Are GnRH Agonists kanye Antagonists
Ngesikhathi ukwelashwa kwe-IVF , udokotela wakho wokubeletha udinga ukulawula umjikelezo we-ovulatory. Uma kungenjalo, amaqanda angavunyelwa kakhulu kakhulu. Ayengeke akwazi ukubuyiselwa futhi ahlolwe emtatsheni we-embryology uma lokhu kwenzeka.
Yingakho kungase kudingeke uthathe u-GnRH agonist noma umphikisi we-GnRH.
Yombili imithi iveza umbuso wamasosha wesikhashana.
Umehluko phakathi kwezidakamizwa ukuthi i-GnRH agonist iqala ukukhiqiza ama-hormone e-FSH ne-LH bese eyeka. Umphikisi we-GnRH akhiqiza lokho kuqala kokuqala.
Phakathi ne-IVF, uzobe uzinikela ukujova kwama-hormone ama-FSH ne-LH ukukhuthaza ama-ovari ukukhiqiza amaqanda.
Ama-agonists ase-GnR ahlanganisa:
- Lupron
- I-Synarel
- Ngaphezulu
- I-Zoladex
Abaphikisi be-GnRH bahlanganisa:
- I-Antagon
- Ganirelix
- I-Orgalutran
- Cetrotide
Ama-agonists angase asetshenziselwe ukwelapha i- endometriosis ne-fibroids.
> Imithombo:
> I-Gonadorelin (Umzila ongathandabuzeki, umzila wokuguga). I-Micromedex Ulwazi Oludakile Lwezidakamizwa Lomthengi [Inthanethi]. I-PubMed Health.
> I-Gonadotropin-Ukukhipha amahomoni. Wena namaHormoni akho. Umphakathi we-Endocrinology.
> Imithi yokwehlisa i-Ovulation: Umhlahlandlela weziguli. I-American Society of Medicine Yokuzala.