Kungani i-heparin ne-aspirin kungasiza
Uma igazi lakho livala, amaprotheni amaningi emzimbeni wakho, phakathi kwabo i-Factor V, asebenza ndawonye ukwenza lokho kwenzeke; I-Factor V Leiden iyinhlobonhlobo yofuzo ye-Factor V echaphazela inqubo yokuvalwa kwegazi futhi yenza umuntu akwazi ukudala ama-blood clots.
Funda kabanzi mayelana nalokhu kuhluka kofuzo futhi kungaba namuphi umphumela ekukhupheni kwakho nalesi sibuyekezo.
Amakhophi we-Factor V Leiden Gene
Umuntu angaba nekhophi eyodwa yegciwane le-Factor V Leiden kanye nekhophi ejwayelekile evamile (okusho ukuthi umuntu u-heterozygous), noma umuntu angaba namakhophi amabili weGenoritus le-Factor V Leiden (lowo muntu unama-homozygous).
Abanye odokotela batusa i-heparin yabesifazane abanezinsizwa eziphindaphindiwe ezivivinya ama-Factor V Leiden. Buza udokotela wakho uma ephakamisa i-heparin, enye imithi noma ayikho imithi nhlobo kuwe.
Ukuphikiswa kwamaprotheni C
I-Factor V Leiden ifulethi ibuye ihlotshaniswe nesimo esibizwa ngokuthi ukuphikiswa kwamaprotheni C okusebenzayo. Amaprotheni C enye iprotheni ehilelekile ekugubungeni. Iningi labantu elinamaprotheni asebenzayo asetshenzisiwe futhi linokuhlukahluka kofuzo lwe-Factor V Leiden. Ngakho-ke, abesifazane abaningi abangazange bahlolwe ngokuqondile ngegciwane le-Factor V Leiden bangathola ukuthi bayithwali emva kokuhlolwa okuhle kweprotheyini C.
Izibalo
Amaphesenti angaba ngu-4 kuya ku-7 amaphesenti wabantu yi-heterozygous ye-Factor V Leiden.
Emaphesenti angu-0.06 kuya kumaphesenti angu-0.25 wabantu yi-homozygous ye-Factor V Leiden. Amaqembu ahlukene ahlukene anamazinga ahlukene okwenziwa kwe-Factor V Leiden; livame kakhulu kubantu abavela enyakatho ye-Europe. Khuluma nodokotela wakho ukuthi ngabe usengozini noma cha.
Izingozi
I-Factor V Leiden isho ingozi eyengeziwe yokwehliswa kwe-vein deep and clots ezibalulekile zemithi.
Ezinye izifundo zithole ukuthi ukuguquguquka kwe-Factor V Leiden kusho ingozi eyengeziwe yokwehlukaniswa kwamaphutha , mhlawumbe ngenxa yamaconsi amancane egazini avimbela ukugeleza kwezakhi emgqeni we-placenta.
Ukwelapha
Ekukhulelwe, abanye odokotela bakholelwa ekusebenziseni i- heparin kanye / noma i -aspirin ephansi ephansi ukuze baphathe abesifazane abanegciwane lesisindo se-Factor V Leiden nomlando wamaphutha. Njengamanje, abacwaningi basacwaninga lokwelashwa ukuqinisekisa ukuthi empeleni kusiza. Imitholampilo eminingi yokuzala iphakamisa ukuthi iziguli zithatha ingane i-aspirin ngenkathi yokwelashwa kuphela uma ngabe inenkinga yokuqeda.
Ubudlelwane nemikhawulo
Abacwaningi basacwaninga ukuthi ubuhlobo bukhona phakathi kweCosor V Leiden (nezinye izifo ezithathelwanayo ezifuywayo) kanye nokuhlukunyezwa okuphindaphindiwe. Ukuhlukunyezwa kwegazi lohlobo oluhlukene kunamazinga ahlukene okuhlobana nokukhulelwa kwesisu, kodwa i-Factor V Leiden ingenye ye-thrombophilias eyifa elibonakala iyingxenye ekwenzeni ukuhlukumeza (noma okungenani kwandisa ingozi) ngoba abesifazane abanezakhi zinezinga eliphezulu ukukhubazeka okungaphezu kwabesifazane abangenawo.
Ucwaningo olutholakalayo lubonisa ukuthi i-Factor V Leiden ingadlala indima ekuphuculeni okwenzeka ngemuva kwamasonto ayishumi kodwa kungenakwenzeka ukuthi ibe yinto ebangela ukuhlukumeza kwangaphambili.
Odokotela abaningi bahlolisisa i-Factor V Leiden njengengxenye yokuphindaphinda kokuhlolwa kokuphuphuma kwesisu nokunciphisa ukwelashwa kulabo abahlolwayo abahle.
Imithombo:
Coulam, CB, RS Jeyendran, LA Fishel, no R. Roussev, Umagazini waseMelika we-Immunology Mayu 2006.
Foka, ZJ, AF Lambropoulos, H. Saravelos, GB Karas, A. Karavida, T. Agorastos, V. Zournatzi, PE Makris, J. Bontis, no A. Kotsis, "I-factoror V leiden ne-prothrombin G20210A ishintsho, kodwa hhayi i-methylenetetrahydrofolate ukunciphisa i-C677T, ihlotshaniswa nokuhlukunyezwa okuphindaphindiwe. " Feb 2000.
UJivraj, S., R. Rai, J. Underwood, noL. Regan, "Izinguquko ze-Genetic thrombophilic phakathi kwemibhangqwana ephindaphinda isisu." Ukukhiqizwa Kwabantu Ngo-May 2006.
U-Reznikoff-Etievan, MF, V. Cayol, B. Carbonne, A. Robert, F. Coulet, noJ. J. Milliez, "I-Factor V Leiden ne-G20210A Izinguquko ze-prothrombin ziyizinto eziyingozi zokukhulelwa kwesisu okuqala." I-BJOG Dec 2001.
I-University of Illinois - i-Urbana / Champaign, "Izimali Ezibekezelayo: I-Factor V Leiden." Ikhasi leNsiza yeHematology .
Walker, MC, SE Ferguson, noVM Allen, "I-Heparin yabesifazane abakhulelwe abane-thrombophili ezuze noma ezuzwe njengefa." I-Cochrane Library 21 Jan 2003.