Ukuphikiswa kwe-Clomid kanye Nezindlela Zokuthuthukisa Ukuphendula Nge-Ovulation
Cishe eyodwa kwabesifazane abane ngeke ivule ngenkathi ithatha i-Clomid . Ngesinye isikhathi, isizathu sokuthi ungahle usivule ku-Clomid ngoba umthamo uphansi kakhulu. Kuvame ukuqala ukwelashwa kwe-Clomid ku-50 mg, bese ukhuphukela ku-100 mg uma ungaphenduli. Kwezinye izimo, odokotela bazozama ukulinganisa ama-250 mg. Kodwa-ke, uma ungakabi ovulating ngisho nasezinyangeni eziphakeme, lokhu kubizwa ngokuthi ukumelana ne-Clomid.
Ukumelana ne-Clomid akufani nesimo esifanayo nesikhathi lapho ungacabangi ukuthatha imithi yokuzala. Kuleso simo, ungase ukhiphe, kepha ungakhulelwa. Kulesi simo, awukho ngisho ne-ovulating.
Ingabe kuzodingeka uthuthele ezidakamizweni ezinamandla noma ukwelashwa okuyinkimbinkimbi uma ukuvota kungenzeki? Akunjalo ngempela.
Yini Ebangelwa Ukuphikiswa Kwe-Clomid?
Indlela yokwelapha yakho yokwelapha ukumelana ne-Clomid incike ekutheni kungani ecabanga ukuthi awuphenduli. Nazi ezinye ezimbalwa ezaziwa, izizathu ezingenzeka zokumelana ne-Clomid:
I-PCOS : Abesifazane abane- PCOS bavame ukukhathazeka ngokumelene ne-Clomid, ikakhulukazi labo abathintekayo njengama-resistant insulin noma amazinga we-hyperandrogenic (amazinga aphezulu ama-DHEAs namazinga ama-hormone wesilisa).
I-BMI ngaphezulu kuka-25 : Inkomba yomzimba yomzimba (BMI) engaphezu kuka-25 inganciphisa amathuba okusebenza kwe-Clomid ngempumelelo.
I-Hyperprolactinemia : Abesifazane abane-hyperprolactinemia bangase bangaphenduli kahle ku-Clomid, ngaphandle kokuphatha ne-hyperprolactinemia.
Yiqiniso, kunezikhathi lapho kungacacile ukuthi kungani i-Clomid engasizi ekukhuliseni i-ovulation.
Izinketho zokuphatha ukuphikiswa kwe-Clomid
Kwabesifazane abane-PCOS, ukwelashwa nge- metformin yokuvimbela i-insulin yezidakamizwa, eyaziwa nangokuthi i-Glucophage, ingasiza. Ngokufanelekile, i-Metformin yayizobekwa enqunywe isikhathi sezinyanga ezintathu ukuya kweziyisithupha ngaphambi kokuzama futhi uClomid.
Ucwaningo oluthile lubonise ukuthi ngaphandle kokuthuthukisa amazinga okuvota, ukuthatha i-metformin ne-Clomid ndawonye kungase kwandise izinga lokukhulelwa futhi kunciphise ingozi yokukhulelwa kwesisu.
Okunye okunye okungahle kwenzeke ku-metformin yi-N-acetyl-cysteine (i-NAC), i-amino acid ne-antioxidant esebenza njenge-agent ye-insulin yokwehlisa amandla. Ezinye izifundo zithole ukuthi ukuhlanganisa i-Clomid ne-NAC kungasiza ukuphatha ukumelana kwama-Clomid.
Uma i- BMI yakho ingaphezu kuka-25 , udokotela wakho angase asikisele ukuthi ulahlekelwe isisindo ngaphambi kokuzama kabusha i-Clomid. Ukulahlekelwa ngamaphesenti angu-10 wesisindo somzimba wakho wamanje kungathuthukisa umphumela kaClomid.
Kulabo abane-hyperprolactinemia, ukwelashwa nge-Bromocriptine yezidakamizwa, okuwukuphela noma okuhlangene ne-Clomid, kungase kuthuthukise amazinga wokuvota.
I-ovarian drill yindlela endala yokwelapha ukumelana kwama-Clomid kubesifazane abane-PCOS, kodwa akusetshenziswanga kakhulu namuhla ngenxa yezingozi. Uma udokotela wakho ephakamisa ukukhwabanisa kwe-ovari, ungase ufune ukubuza umbuzo walokho kukhetha, uma kunezinye izinketho ezingakwazi futhi zifanele ziqale kuqala.
Amaphilisi Wokulawula Ukubeletha Okungenzi lutho?
Indlela eyodwa ezithakazelisayo yokubhekana nokuphikiswa kwe-Clomid kuthatha amaphilisi okulawula ukubeletha isikhathi esisodwa kuya kwezinyanga ezimbili ngaphambi kokuzama omunye umjikelezo we-Clomid.
Lokhu kunconywa kwabesifazane abanezinga eliphezulu lama-DHEA ama-hormone.
Kubonakala sengathi amaphilisi okulawulwa kokuzalwa okuyi-counter-intuitive azokusiza ukuthi ukhulelwe? Kodwa ucwaningo luye lwabonisa imiphumela emihle. Kwesinye isifundo mayelana nokusetshenziswa kwamaphilisi okulawula ukubeletha, amaphesenti angaphezu kuka-65 amantombazane aphikisana ne-Clomid avuliwe, ngemuva kokuthatha amaphilisi okulawula ukubeletha ngomlomo izinyanga ezimbili ezandulela umjikelezo wezokwelapha.
Kuthiwani uma i-Clomid isalokhu ingasebenzi?
Ngezinye izikhathi, i-ultrasound izobonisa ukuthi i-follicles ikhula ekuphenduleni ku-Clomid, kodwa ukuqhuma kwe- LH emaphakathi akunamandla okwanele ukuletha ukuvuthwa. Kulolu daba, udokotela wakho angase anikeze i-Clomid kanye nomjovo we-hCG, njengesidakamizwa u-Ovidrel, ukuqala ukuvuthwa kwegazi nokuqinisa ukuqhuma kwe-LH emaphakathi.
Uma ngemuva kokuzama lokhu okukhethwa kukho, awusayi ku-ovulating ku-Clomid, udokotela wakho angase asikisele ukuzama imithi ehlukahlukene yokuvuselela i-ovarian.
I-Letrozole (eyaziwa nangokuthi i-Femera) yinye inketho yabesifazane abangenayo i-Clomid. Ucwaningo luye lwabonisa ukuthi i-Letrozole ingabangela ukuvuthwa kwamanye amantombazane nge-PCOS abangaphenduli ku-Clomid, kanye nabesifazane abathile abane-infertility engacacisiwe kanye nokumelene kwama-Clomid.
Kwesinye isifundo, abesifazane abane- Clomid ukumelana ne-PCOS bebaningi amathuba okugcoba lapho bethatha imithi i-Letrozole (79.3% ekhulisiwe), kunokuba lapho kuthatha i-Clomid inhlanganisela emibili, ukujola okuphansi kwe-FSH yokwelashwa kwe-FSH (amaphesenti angu-56.59 avuliwe). Izinga lokukhulelwa laphinde lathuthukiswa, ngamaphesenti angama-23 abesifazane abathwala i-Letrozole ekufezeni ukukhulelwa, kanti amaphesenti angu-14 aphumelela ukukhulelwa ne-Clomid kanye namajovo amabili we-FSH inhlanganisela encane.
Nokho, i-Letrozole ayithengiswa njengomuthi wokuzala. Kunengxabano ngokuphepha kokusetshenziswa kwayo. I-Letrozole ingabangela ukukhubazeka kokuzalwa uma kuthathwa ngesikhathi sokukhulelwa. Abaningi bathi umuthi uphephile futhi uthi isidakamizwa kufanele siphume ohlelweni lwakho ngesikhathi sokukhulelwa kwenzeka, nakuba ucwaningo olwengeziwe luzodingeka lwenziwe.
Ezinye izinketho zokuphatha ukumelana kwama-Clomid zihlanganisa ukwelashwa kwe-gonadotropin ephansi , noma ngaphandle kokwelashwa kwe-IUI . Lokhu kufaka phakathi izidakamizwa ezifana ne-Gonal-F, Follistim, ne-Ovidrel. (Ngamanye amazwi, izidakamizwa ze- FSH kanye ne-LH zokuzala .) Lezi zidakamizwa ziyabiza kakhulu futhi ziza nemiphumela emibi kakhulu kune-Clomid, kodwa zingase zenze ukuvuthwa uma i-Clomid ihluleka.
Izwi elivela ku-Verywell
I-Clomid ivame ukuqala umuthi wokuzala ohlolwe ngemuva kokuxilongwa kwe-infertility. Kungenzeka ukuthi uzama ukukhulelwa isikhathi esingaphezu konyaka ngesikhathi lo mjikelezo wezokwelapha uqala. Uma ingasebenzi, ungase ukhathazeke ngokuthi lokhu kuyisibonakaliso sezinto ezizayo. Ungakhathazeka lokhu kusho ukuthi uhloselwe ukwelashwa okubiza kakhulu, njenge-IVF .
Iqiniso liwukuthi i-Clomid ibonisa kuphela ukuqala kokwelashwa okungenasifo. Uma ungahambisani nomjikelezo wakho wokuqala noma wesibili, noma ungakhulelwa, zama ukungesabi. Kunezinyathelo eziningi endleleni ngaphambi kokuba ucelwe ukuba ucabange ngemithi yokwelapha ephakeme ye-Tech .
> Imithombo:
> Abu Hashim H1, Foda O2, Ghayaty E3. "I-metformin-clomiphene ehlanganiswe ne-clomiphene-antiant polycystic syndrome ye-ovary syndrome: ukubuyekezwa okuhlelekile nokuhlaziywa kwemeta yezilingo ezilawulwa ngokungahleliwe. "I-Acta Obstet Gynecol Scand. 2015 Sep; 94 (9): 921-30. i-doi: 10.1111 / aogs.12673. I-Epub 2015 Jun 2.
Ganesh A, Goswami SK, Chattopadhyay R, Chaudhury K, Chakravarty B. Ukuqhathaniswa kwe-letrozole ne-gonadotropins eqhubekayo kanye ne-clomiphene-gonadotropin inhlanganisela yokuvuthwa kwe-ovulation ngo-1387 ama-PCOS abesifazane ngemuva kokuhluleka kwe-citomiphene kwe-citrate. I-Journal Yokukhiqizwa Okusiziwe Nezofuzo. 2009 Jan 7. [Epub ngaphambi kokuphrinta]
Goenka Deepak, Goenka ML. " Iphilisi yokuvimbela imithi yokwelashwa ngokweqile yezinkinga zokuvimbela i-clomiphene citrate elandelwa ukuphinda ukwelashwa kwe-citomiphene citrate. " I-Journal of Obstetrics ne-Gynecology of India. I-Vol. 56, No. 2: Mashi / April 2006 Pg 159-161. Kufinyelelwe ku-intanethi ngoFebhuwari 19, 2009.
Ukusebenzisa ukukhulelwa komlomo njenge-Treatment ye-Clomid-Resistant Patients. Umkhandlu we-InterNational on Information Infertility Ukusakaza: Infertility Journal Summaries.